Serum Glucagon Counterregulatory Hormonal Response to Hypoglycemia Is Blunted in Congenital Hyperinsulinism
نویسندگان
چکیده
منابع مشابه
Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism.
The mechanisms involved in the release of glucagon in response to hypoglycemia are unclear. Proposed mechanisms include the activation of the autonomic nervous system via glucose-sensing neurons in the central nervous system, via the regulation of glucagon secretion by intra-islet insulin and zinc concentrations, or via direct ionic control, all mechanisms that involve high-affinity sulfonylure...
متن کاملGlucagon response to hypoglycemia in sympathectomized man.
Hypoglycemia stimulates immunoreactive glucagon (IRG) secretion and increases the activity of the sympathetic nervous system. To ascertain if the augmented alpha cell activity evoked by glucopenia is mediated by the adrenergic nervous system, the glucagon response to insulin-induced hypoglycemia of five subjects with neurologically complete cervical transections resulting from trauma, thereby d...
متن کاملDiazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes.
Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs). Strategies to prevent hypoglycemia are often ineffective, highlighting the need for novel therapies. ATP-sensitive potassium (KATP) channels within the hypothalamus are thought to be integral to hypoglycemia detection an...
متن کاملDiazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long- standing Type 1 Diabetes Short Title; Diazoxide improves hypoglycemia responses
Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRR). Strategies to prevent hypoglycemia are often ineffective highlighting the need for novel therapies. ATP-sensitive potassium (KATP) channels within the hypothalamus are thought to be integral to hypoglycemia detection and ...
متن کاملVentromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.
OBJECTIVE The counterregulatory response to insulin-induced hypoglycemia is mediated by the ventromedial hypothalamus (VMH), which contains specialized glucosensing neurons, many of which use glucokinase (GK) as the rate-limiting step in glucose's regulation of neuronal activity. Since conditions associated with increased VMH GK expression are associated with a blunted counterregulatory respons...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2005
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.54.10.2946